This tumor most often develops in the parotid gland, where it represents 2% to 3% of all parotid neoplasms. Mucoepidermoid carcinoma of the major salivary glands. Mucoepidermoid carcinoma is more frequent in females, occurs in the. Mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. This biopsy result shows low grade mucoepidermoid carcinoma of the right parotid gland and the ent has suggested to completely remove the right parotid gland. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of. All but one were located within the parotid gland and none were within the pps nor me tastatic at presentation.
Major salivary gland tumors were staged according to the. We report the case of a 60yearold man who presented with a swelling in the parotid region. In this article, we report a case of sclerosing mucoepidermoid carcinoma mec arising in the parotid gland, with crtc1maml2 gene fusion. Mucoepidermoid carcinoma is the most common malignant tumor of salivary gland. On fnac, a diagnosis of mucoepidermoid carcinoma was given. Clinical, histological, and radiological findings of palatal mec in a 12yearold girl are presented with threeyear followup.
Mucoepidermoid carcinoma with distant metastases to the kidney, adrenal gland, skull and gluteus maximus muscle. Mucoepidermoid carcinoma presenting as a large cyst of the. Mucoepidermoid carcinoma of the salivary glands in brazil scielo. Histopathologic grading of salivary gland neoplasms. In the face of small, lowgrade cancers, the risk of lymph. Mucoepidermoid carcinoma of the salivary gland sciencedirect. Most patients 75% were tumor free after the initial treatment. Its clinical behavior is determined by the relative ratio of mucous and epidermoid cells with pathologic high. We report a case of mec arising in wt of the parotid gland, describing clinical and pathological aspects. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults.
In patients with masg tumors, the 5year diseasefree survival rate was 22. Role of intraparotid node metastasis in mucoepidermoid carcinoma. Mucoepidermoid carcinoma of the parotid radiology case. Sclerosing mucoepidermoid carcinoma in the parotid gland. Metastasis from salivary gland malignancy is infrequent and predominantly found in bone, lung, liver and lymph nodes. Mucoepidermoid carcinoma mec of the salivary gland. The locoregional recurrencefree survival lrfs and the distant. Mucoepidermoid carcinoma with distant metastases to the. It infiltrates the left parapharyngeal space, left eustachian tube, left fossa of rosenmuller as well as left longus capitis muscle.
However, the palate is a frequent site when it occurs in the minor glands. Mucoepidermoid carcinoma occurred in the parotid gland in 196 cases 84%, in the. Mucoepidermoid carcinoma occurred in the parotid gland in 196 cases 84%, in the submandibular gland in 31 %, and in the sublingual gland in 7 3%. Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Majority of the salivary gland tumors arise in parotid gland with maximum. The second case documents the most common benign and malignant ipsilateral parotid gland neoplasm reported in this case series, a warthins tumor and a mucoepidermoid carcinoma.
It is less common in the submandibular gland and in the minor salivary glands. Mucoepidermoid carcinoma of parotid gland salman alkhalifa, frcs, dlo1 noor yousif abdulkarim, md, msc ucl2 fatima n abulfateh, md1 1king hamad university hospital, 2bdf hospital abstract objective. Although the parotid gland is the most common site of involvement, other major salivary glands and the minor salivary glandsmost commonly of the palatealso can be involved. Mucoepidermoid carcinoma of the parotid gland request pdf. Patients in group 3 had a substantially higher percentage 33% of tumors in the submandibular gland than.
A 73yearold woman with a mass in the right parotid regio. Role of intraparotid node metastasis in mucoepidermoid. A 14yearold boy with an unremarkable medical history developed a slowly growing mass in the region of the left parotid gland. The lesion extends upwards and infiltrates the left infratemporal fosaa and both pterygoid muscles. Recurrent mucoepidermoid carcinoma of parotid with facial. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland. Carcinomatous components can be represented by squamous cell carcinoma the most common 1820, oncocytic carcinoma, adenocarcinoma, undifferentiated carcinoma and mucoepidermoid carcinoma mec 2125. Mucoepidermoid carcinoma in warthin tumor of the parotid gland article pdf available in archives of medical science 1. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. Adjuvant treatment for parotid mucoepidermoid carcinoma. Mucoepidermoid carcinoma of the parotid gland is very rare in children.
Mucoepidermoid carcinoma mec is the most common malignant salivary gland tumor. Primary squamous cell carcinoma of the parotid gland is a rare aggressive malignancy with a reported incidence of 0. The histologic picture confirmed that the tumor was mec of parotid gland. Mucoepidermoid carcinoma of the parotid gland treated by. Mec mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. As a teenager who developed low grade mucoepidermoid carcinoma mec of the salivary glands, how might this diagnosis affect my longterm survival. Mucoepidermoid carcinoma mec, an extremely rare tumor, arises from the epithelial component of preexisting parotid warthin tumors wt. Read hpvp16 overexpression in mucoepidermoid carcinoma of the parotid gland, international journal of radiation oncology biology physics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Mucoepidermoid carcinoma is a type of cancer of the salivary glands salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Hpvp16 overexpression in mucoepidermoid carcinoma of the. Minor salivary gland tumours account for 1015% of all salivary gland neoplasms and are usually malignant. Carcinoma ex pleomorphic adenoma is a highgrade salivary gland carcinoma in which malignant transformation occurs in a previously benign pleomorphic adenoma. Mucoepidermoid carcinoma in a minor salivary gland in a child.
Pdf sclerosing mucoepidermoid carcinoma of the parotid gland. Mucoepidermoid carcinoma is the most common type of salivary gland cancer in adults. Mucoepidermoid carcinoma, salivary gland neoplasms. Mucoepidermoid carcinoma, abbreviated mec, the is the most common malignant neoplasm of the salivary gland. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Mucoepidermoid carcinoma is the most common malignant tumor of the parotid gland. These cancers are usually low grade, but they can also be intermediate or high grade. The 5year overall and diseasefree survival rate was 62.
Mec can also involve a variety of other sites that have minor mucoserous glands. The treatment for mucoepidermoid carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. Recurrent mucoepidermoid carcinoma of parotid with facial tics report of an unusual case published. It can also occur in other organs such as the thyroid, bronchi and lacrimal sac. Results from this study indicate that the five year disease free survival rate for patients with lowgrade mec of the salivary glands is 98. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland mucicarmine staining is one stain used by pathologist for detection. Clinical stage and histologic grade are the main prognostic factors. With prompt diagnosis and adequate treatment, the prognosis of mec of salivary gland is generally good. More than half of these cases involve the major salivary glands, primarily the parotid glands. Mucoepidermoid carcinoma of the head and neck oxford. Mucoepidermoid carcinoma genetic and rare diseases. Parotid gland cancer is an uncommon neoplasm, but according to their architectural and cytological features, there were 24 types of malignant tumors classified by the world health organization 2, 3, mucoepidermoid carcinoma mec is the most common pathologic subtype, some clinicpathologic variables, including histologic grade, lymphovascular and perineural invasion as well. Adenoid cystic carcinoma is usually slow growing and often appears to be lowgrade when looked at under the microscope.
Histopathologic grading of salivary gland neoplasms has been done with various degrees of success and hence various degrees of acceptance among. The aim of this report is to present a case of mucoepidermoid carcinoma of the. Mucoepidermoid carcinoma mec is the most common primary salivary gland malignancy, accounting for approximately 25% of all malignancies. Prognostic factors for parotid mucoepidermoid carcinoma mec usually include disease grade, tumor. Mucoepidermoid carcinoma presenting as a large cyst of the parotid gland in hiv disease. Warthinlike mucoepidermoid carcinoma of the parotid gland. Mucoepidermoid carcinoma of the parotid gland, cancer 10. Treatment and survival outcomes based on histologic. Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Mucoepidermoid carcinoma in warthin tumor of the parotid gland. Postoperative radiotherapy for mucoepidermoid carcinoma of the. Mucoepidermoid carcinoma of the major salivary glands goode. Mucoepidermoid carcinoma what is, treatment, survival.
In 1953, foot and frazell named these tumors as mec. Diseasespecific and recurrence free survival were stratified by tumor. In 1895, volkman described these tumors for first time. Salivary gland carcinoma an overview sciencedirect topics. Certainly, the treatment of mec and the ability to obtain tumorfree margins vary by site, as does the distribution of tumor grade and stage. Who gets mucoepidermoid carcinoma of salivary gland. We are presenting a rare case of metastasis of mucoepidermoid carcinoma of parotid gland to the contralateral mandible. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of major and minor salivary glands and can also occur as an intraosseous tumor frequently called as central mec.
Mucoepidermoid carcinoma of the minor salivary gland. Skin nonmelanocytic tumors mucoepidermoid carcinoma. The most common cancer among salivary glands tumours and especially the major salivary glands is the mucoepidermoid carcinoma of the parotid gland 75% 2 mucoepidermoid carcinoma is a. Diagnosis and management of malignant salivary gland tumors of the. Mucoepidermoid carcinoma mec is the most common malignancy of the major and minor salivary glands, comprising 34% of salivary gland malignancies. Parotid gland cancer is an uncommon neoplasm 1, but. Original article, case study by ear, nose and throat journal. Pdf mucoepidermoid carcinoma in warthin tumor of the. Abnormal large mass at the region of the left parotid gland with heterogenous pattern of enhancement. Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. Mucoepidermoid carcinoma of the parotid gland in children. Health, general cancer diagnosis carcinoma hiv viruses hiv infection case studies complications and side effects hiv infections squamous cell carcinoma care and treatment causes of. Pdf largest mucoepidermoid carcinoma of parotid gland in the.